Cattle & Sheep Vaccines

Sheep For the active immunisation of sheep to: • reduce clinical signs and mortality due to the toxin of Clostridium tetani (Tetanus); • reduce mortality due to the epsilon toxin of Clostridium perfringens (Pulpy kidney); • induce a serological response against the beta toxin of Clostridium perfringens (Struck, Lamb dysentery). The vaccine may be used in pregnant ewes to provide passive immunisation of lambs, provided that the lambs receive sufficient immune colostrum during the first 12 hours of life, to: • reduce clinical signs and mortality due to the toxin of Clostridium tetani (Tetanus); • reduce mortality due to the epsilon toxin of Clostridium perfringens (Pulpy kidney); • induce a serological response against the beta toxin of Clostridium perfringens (Lamb dysentery). Significant levels of immunity cannot be expected until two weeks after the second dose of vaccine in the primary vaccination course. From experience from field use, the duration of active immunity in lambs and sheep is expected to last one year. The duration of passive protection in lambs is approximately 12 weeks provided that the lambs receive sufficient immune colostrum during the first 12 hours of life. Pigs For active immunisation of sows against tetanus caused by Clostridium tetani. Significant levels of immunity cannot be expected until two weeks after the second dose of vaccine in the primary vaccination course. From experience from field use, the duration of active immunity in pigs is expected to last one year. The vaccine may be used in pregnant sows to provide passive immunisation of piglets, provided that the piglets receive sufficient immune colostrum during the first 12 hours of life, to: • reduce clinical signs and mortality due to the toxin of Clostridium tetani (Tetanus); • induce a serological response against the toxin of Clostridium perfringens type C (enterotoxaemia). The duration of the passive protection in piglets is 14 days. Dosage & Administration The vaccine should be administered by subcutaneous injection in the lateral side of the upper neck observing aseptic precautions. Ewes and sows can be vaccinated during late pregnancy. • Sheep and lambs: 2 ml/dose. • Pigs: 5 ml/dose. Sheep • All sheep from 3 weeks of age onwards and not previously vaccinated with Lambivac must receive two injections separated by an interval of 4-6 weeks to be completed before onset of the period of risk. • Thereafter they should receive booster injections 2-3 weeks prior to identified risk periods with intervals of not more than 12 months. • In adult breeding ewes these yearly booster injections should be given during the pre-lambing period, 4-6 weeks pre-lambing, to allow passive protection of lambs via colostrum. Pigs • Two injections with an interval of at least 3 weeks between injections, the second dose to be administered at least 3 weeks before farrowing. • The preferred schedule is vaccination at 6 and 3 weeks prior to the expected date of farrowing. • Only a single booster dose is required in subsequent pregnancies at approximately 3-4 weeks pre-farrowing.

• For the active immunization of cattle from 1 month of age against Leptospira interrogans serovar hardjo and Leptospira borgpetersenii serovar hardjo. • To reduce shedding of Leptospira interrogans serovar hardjo in urine. • To improve herd fertility when infertility is diagnosed as caused by Leptospira hardjo. Circulating antibody is detectable 14 days following the first injection and persists for 12 months following completion of the primary course. Conjunctival challenge demonstrates 12 months cross protection against Leptospira borgpetersenii serovar hardjo (hardjo Bovis). In addition to circulating antibody response, vaccination with Leptavoid-H also stimulates cell-mediated immunity to Leptospira borgpetersenii serovar hardjo which is maintained for at least five months and responds in the event of a challenge five months post vaccination. Dosage & Administration Dose: • Cattle 2 ml. Minimum age of administration: 1 month. Administration: • By subcutaneous injection. • The container should be well shaken to resuspend the precipitate before doses are withdrawn. • The vaccine should be deposited beneath the skin covering the chest wall, well behind the shoulder, or beneath the skin covering the side of the neck. Dosage schedule: • The primary course consists of two doses with an interval of at least 4 weeks and not more than 6 weeks between them. • Ideally the course should be completed in the spring before the main season of transmission of Leptospira hardjo. Booster vaccination: • Re-vaccination with a single dose should be given annually to maintain protection against infection and progressively reduce exposure in the herd. • If the primary course is given later than the spring, the first booster should be given in the following spring and annually thereafter. Youngstock vaccination: • If the calves are inoculated before 5 months of age, a further primary course should be given at that age (allowing an interval of 4 weeks between vaccinations), as otherwise maternally derived antibodies may interfere with the immune response. • Older calves not immediately exposed to infection can be given the initial course at any time, but it is advisable to complete vaccination shortly before the main season of transmission of leptospirosis. To improve herd fertility: • For maximum benefit the primary course should be completed within 12 months of infertility being diagnosed as caused by Leptospira hardjo.

• For the active immunization of cattle from 1 month of age against Leptospira interrogans serovar hardjo and Leptospira borgpetersenii serovar hardjo. • To reduce shedding of Leptospira interrogans serovar hardjo in urine. • To improve herd fertility when infertility is diagnosed as caused by Leptospira hardjo. Circulating antibody is detectable 14 days following the first injection and persists for 12 months following completion of the primary course. Conjunctival challenge demonstrates 12 months cross protection against Leptospira borgpetersenii serovar hardjo (hardjo Bovis). In addition to circulating antibody response, vaccination with Leptavoid-H also stimulates cell-mediated immunity to Leptospira borgpetersenii serovar hardjo which is maintained for at least five months and responds in the event of a challenge five months post vaccination. Dosage & Administration Dose: • Cattle 2 ml. Minimum age of administration: 1 month. Administration: • By subcutaneous injection. • The container should be well shaken to resuspend the precipitate before doses are withdrawn. • The vaccine should be deposited beneath the skin covering the chest wall, well behind the shoulder, or beneath the skin covering the side of the neck. Dosage schedule: • The primary course consists of two doses with an interval of at least 4 weeks and not more than 6 weeks between them. • Ideally the course should be completed in the spring before the main season of transmission of Leptospira hardjo. Booster vaccination: • Re-vaccination with a single dose should be given annually to maintain protection against infection and progressively reduce exposure in the herd. • If the primary course is given later than the spring, the first booster should be given in the following spring and annually thereafter. Youngstock vaccination: • If the calves are inoculated before 5 months of age, a further primary course should be given at that age (allowing an interval of 4 weeks between vaccinations), as otherwise maternally derived antibodies may interfere with the immune response. • Older calves not immediately exposed to infection can be given the initial course at any time, but it is advisable to complete vaccination shortly before the main season of transmission of leptospirosis. To improve herd fertility: • For maximum benefit the primary course should be completed within 12 months of infertility being diagnosed as caused by Leptospira hardjo.

Active immunisation of cattle to reduce virus shedding and respiratory clinical signs caused by bovine respiratory syncytial virus infection. Onset of immunity: 21 days after administration of one dose by the nasal route. 21 days after the second dose of the two dose intramuscular vaccination schedule. Duration of immunity: 2 months after nasal vaccination. 6 months after intramuscular vaccination.

Active immunisation of cattle to reduce virus shedding and respiratory clinical signs caused by bovine respiratory syncytial virus infection. Onset of immunity: 21 days after administration of one dose by the nasal route. 21 days after the second dose of the two dose intramuscular vaccination schedule. Duration of immunity: 2 months after nasal vaccination. 6 months after intramuscular vaccination.

For use with NASYM BRSV intrajnasal vaccine.

For the active immunisation of lambs as an aid in the control of pulpy kidney, tetanus, braxy and blackleg caused by Cl.perfringens type D, Cl.septicum, Cl.tetani and Cl.chauvoei. The vaccine may be used as an aid in the control of pneumonic pasteurellosis in sheep of all ages from a minimum age of 3 weeks and in the control of systemic pasteurellosis in weaned fattening and breeding sheep. Dosage & Administration Dose : 2 ml Administration: The vaccine should be administered by subcutaneous injection in the lateral side of the upper neck observing aseptic precautions. All lambs not previously vaccinated with Ovivac P Plus must receive two injections, each of 2.0 ml, separated by an interval of 4-6 weeks. Thereafter they must receive booster injections at intervals of not more than 12 months. On farms where the incidence of pasteurellosis is high, a supplementary booster vaccination with Ovipast Plus (Pasteurella vaccine) may be required 2-3 weeks prior to expected seasonal outbreaks. Ovivac P Plus should not be used in lambs less than 3 weeks of age due to the possible immunological incompetence of the very young lamb and competition from any maternally derived colostral antibodies.

For the active immunisation of lambs as an aid in the control of pulpy kidney, tetanus, braxy and blackleg caused by Cl.perfringens type D, Cl.septicum, Cl.tetani and Cl.chauvoei. The vaccine may be used as an aid in the control of pneumonic pasteurellosis in sheep of all ages from a minimum age of 3 weeks and in the control of systemic pasteurellosis in weaned fattening and breeding sheep. Dosage & Administration Dose : 2 ml Administration: The vaccine should be administered by subcutaneous injection in the lateral side of the upper neck observing aseptic precautions. All lambs not previously vaccinated with Ovivac P Plus must receive two injections, each of 2.0 ml, separated by an interval of 4-6 weeks. Thereafter they must receive booster injections at intervals of not more than 12 months. On farms where the incidence of pasteurellosis is high, a supplementary booster vaccination with Ovipast Plus (Pasteurella vaccine) may be required 2-3 weeks prior to expected seasonal outbreaks. Ovivac P Plus should not be used in lambs less than 3 weeks of age due to the possible immunological incompetence of the very young lamb and competition from any maternally derived colostral antibodies.

Use from 12 weeks of age • as a follow-on to Rispoval® IntraNasal for ongoing protection • as a standalone vaccine where BVDv protection is not required and injectable vaccination is preferred • in combination with other Rispoval vaccines For the active immunisation of calves from 12 weeks of age to: • reduce virus excretion caused by bovine Pi3 virus, • reduce virus excretion caused by BRSV infection. Onset of immunity is 3 weeks after vaccination. Duration of immunity is 6 months after the basic vaccination scheme for BRSV. Duration of immunity has not been established for bovine Pi3 virus. Dosage & Administration Basic vaccination Two doses of 4 ml of reconstituted vaccine should be given 3-4 weeks apart from 12 weeks of age, via the intramuscular route. Re-vaccination • If continued protection against BRSV is required, then animals should be revaccinated after 6 months. The duration of immunity of the Pi3 component is not known. • Animals should preferably be vaccinated at least 3 weeks before a period of stress or high infection risk like re-grouping, transport of animals or the start of the autumn season.

For the active immunisation of calves from 12 weeks of age to: • Reduce virus excretion and the clinical signs caused by PI3 virus • Reduce virus excretion caused by BRSV infection, reduce virus excretion and the severity of leucopenia induced by BVDV type 1 infection Onset of immunity: 3 weeks after vaccination. Duration of immunity: 6 months (demonstrated by challenge studies) after vaccination for BRSV and BVDV Type 1. Duration of immunity has not been established for PI3. Efficacy has not been demonstrated against BVDV Type 2 strains. Dosage & Administration 4ml intramuscular Reconstitute the vaccine by mixing the freeze-dried component with the liquid fraction and shake well. Administer the reconstituted vaccine by the intramuscular route.

For the active immunisation of cattle against Infectious Bovine Rhinotracheitis (IBR) to reduce the clinical signs and virus shedding and, in female cattle, to prevent abortions associated with BHV-1 infection. The vaccination of pregnant cattle will prevent abortion associated with BHV-1 infection as demonstrated during the second trimester of gestation following challenge 28 days after vaccination. Duration of immunity: 6 months. NOTE: This is the inactivated vaccine. Dosage & Administration Cattle over 3 months of age: 2 ml. Route subcutaneous injection.

For the active immunisation of cattle against Infectious Bovine Rhinotracheitis (IBR) to reduce the clinical signs and virus shedding and, in female cattle, to prevent abortions associated with BHV-1 infection. The vaccination of pregnant cattle will prevent abortion associated with BHV-1 infection as demonstrated during the second trimester of gestation following challenge 28 days after vaccination. Duration of immunity: 6 months. NOTE: This is the inactivated vaccine. Dosage & Administration Cattle over 3 months of age: 2 ml. Route subcutaneous injection.