Cattle & Sheep Vaccines

For the active immunisation of cattle against Infectious Bovine Rhinotracheitis (IBR), to reduce virus shedding and clinical signs including, in female cattle, abortions associated with BHV-1 infection. A reduction in abortions associated with BHV-1 infection has been demonstrated during the second trimester of gestation following challenge 28 days after vaccination. Onset of immunity: 4 weeks (at the latest) after completion of the primary course of vaccination, as demonstrated by challenge. Duration of immunity: 6 months. NOTE: This is the Live vaccine. Dosage & Administration 2 ml reconstituted vaccine. Route: Intranasal and/or intramuscular inoculation. The vaccine must be administered aseptically via the intramuscular route (2 ml) or sprayed into the nostrils (1 ml per nostril during aspiration) with the intranasal applicator.

For the active immunisation of cattle against Infectious Bovine Rhinotracheitis (IBR), to reduce virus shedding and clinical signs including, in female cattle, abortions associated with BHV-1 infection. A reduction in abortions associated with BHV-1 infection has been demonstrated during the second trimester of gestation following challenge 28 days after vaccination. Onset of immunity: 4 weeks (at the latest) after completion of the primary course of vaccination, as demonstrated by challenge. Duration of immunity: 6 months. NOTE: This is the Live vaccine. Dosage & Administration 2 ml reconstituted vaccine. Route: Intranasal and/or intramuscular inoculation. The vaccine must be administered aseptically via the intramuscular route (2 ml) or sprayed into the nostrils (1 ml per nostril during aspiration) with the intranasal applicator.

For active immunisation of maternally derived antibody positive or negative calves from 9 days of age against BRSV and PI3V, to reduce the mean titre and duration of excretion of both viruses. Onset of immunity: 5 days for BRSV and 10 days for PI3V after a single vaccination. Duration of protective immunity: 12 weeks following a single dose. The duration of protective immunity against the PI3V fraction may be reduced in MDA positive calves vaccinated before 3 weeks of age. Dosage & Administration A single dose of 2ml of reconstituted vaccine should be given intranasally using the intranasal applicators provided to cattle from the age of 9 days. It is recommended to change applicators between animals to avoid transmitting infectious organisms.

For active immunisation of maternally derived antibody positive or negative calves from 9 days of age against BRSV and PI3V, to reduce the mean titre and duration of excretion of both viruses. Onset of immunity: 5 days for BRSV and 10 days for PI3V after a single vaccination. Duration of protective immunity: 12 weeks following a single dose. The duration of protective immunity against the PI3V fraction may be reduced in MDA positive calves vaccinated before 3 weeks of age. Dosage & Administration A single dose of 2ml of reconstituted vaccine should be given intranasally using the intranasal applicators provided to cattle from the age of 9 days. It is recommended to change applicators between animals to avoid transmitting infectious organisms.

For active immunisation of maternally derived antibody positive or negative calves from 9 days of age against BRSV and PI3V, to reduce the mean titre and duration of excretion of both viruses. Onset of immunity: 5 days for BRSV and 10 days for PI3V after a single vaccination. Duration of protective immunity: 12 weeks following a single dose. The duration of protective immunity against the PI3V fraction may be reduced in MDA positive calves vaccinated before 3 weeks of age. Dosage & Administration A single dose of 2ml of reconstituted vaccine should be given intranasally using the intranasal applicators provided to cattle from the age of 9 days. It is recommended to change applicators between animals to avoid transmitting infectious organisms.

For the active immunisation of pregnant cows and heifers to raise antibodies against E. coli adhesin F5 (K99) antigen, rotavirus and coronavirus. While calves are fed colostrum from vaccinated cows during the first two to four weeks of life, these antibodies have been demonstrated to: • reduce the severity of diarrhoea caused by E. coli F5 (K99); • reduce the incidence of scours caused by rotavirus; • reduce the shedding of virus by calves infected with rotavirus or coronavirus. Onset of Immunity: • Passive protection against all active substances will commence from the start of colostrum feeding. Duration of Immunity: • In calves artificially fed with pooled colostrum, protection will continue until colostrum feeding ceases. • In naturally suckled calves, protection against rotavirus will persist for at least 7 days and against coronavirus for at least 14 days. Dosage & Administration Dose - 2 ml by intramuscular injection.The recommended site is the side of the neck. A single injection should be given during each pregnancy between 12 and 3 weeks before calving is expected. Colostrum feeding • Protection of calves depends on the physical presence of colostrum antibodies (from vaccinated cows) within the gut for the duration of the first 2 - 3 weeks of life until calves develop their own immunity. Thus it is essential to ensure adequate colostrum feeding for the whole of this period to maximise the efficacy of vaccination. All calves must receive adequate colostrum from their dams within 6 hours of birth. Suckled calves will continue to receive adequate colostrum naturally by feeding from vaccinated cows.

For the active immunisation of pregnant cows and heifers to raise antibodies against E. coli adhesin F5 (K99) antigen, rotavirus and coronavirus. While calves are fed colostrum from vaccinated cows during the first two to four weeks of life, these antibodies have been demonstrated to: • reduce the severity of diarrhoea caused by E. coli F5 (K99); • reduce the incidence of scours caused by rotavirus; • reduce the shedding of virus by calves infected with rotavirus or coronavirus. Onset of Immunity: • Passive protection against all active substances will commence from the start of colostrum feeding. Duration of Immunity: • In calves artificially fed with pooled colostrum, protection will continue until colostrum feeding ceases. • In naturally suckled calves, protection against rotavirus will persist for at least 7 days and against coronavirus for at least 14 days. Dosage & Administration Dose - 2 ml by intramuscular injection.The recommended site is the side of the neck. A single injection should be given during each pregnancy between 12 and 3 weeks before calving is expected. Colostrum feeding • Protection of calves depends on the physical presence of colostrum antibodies (from vaccinated cows) within the gut for the duration of the first 2 - 3 weeks of life until calves develop their own immunity. Thus it is essential to ensure adequate colostrum feeding for the whole of this period to maximise the efficacy of vaccination. All calves must receive adequate colostrum from their dams within 6 hours of birth. Suckled calves will continue to receive adequate colostrum naturally by feeding from vaccinated cows.

For the active immunisation of pregnant cows and heifers to raise antibodies against E. coli adhesin F5 (K99) antigen, rotavirus and coronavirus. While calves are fed colostrum from vaccinated cows during the first two to four weeks of life, these antibodies have been demonstrated to: • reduce the severity of diarrhoea caused by E. coli F5 (K99); • reduce the incidence of scours caused by rotavirus; • reduce the shedding of virus by calves infected with rotavirus or coronavirus. Onset of Immunity: • Passive protection against all active substances will commence from the start of colostrum feeding. Duration of Immunity: • In calves artificially fed with pooled colostrum, protection will continue until colostrum feeding ceases. • In naturally suckled calves, protection against rotavirus will persist for at least 7 days and against coronavirus for at least 14 days. Dosage & Administration Dose - 2 ml by intramuscular injection.The recommended site is the side of the neck. A single injection should be given during each pregnancy between 12 and 3 weeks before calving is expected. Colostrum feeding • Protection of calves depends on the physical presence of colostrum antibodies (from vaccinated cows) within the gut for the duration of the first 2 - 3 weeks of life until calves develop their own immunity. Thus it is essential to ensure adequate colostrum feeding for the whole of this period to maximise the efficacy of vaccination. All calves must receive adequate colostrum from their dams within 6 hours of birth. Suckled calves will continue to receive adequate colostrum naturally by feeding from vaccinated cows.

For active immunisation of cattle to prevent kidney colonisation and shedding of Leptospira borgpetersenii serovar Hardjo in urine. A 3 week onset of immunity and 12 month duration of protection has been demonstrated by challenge with Leptospira borgpetersenii serovar Hardjo. For active immunisation of cattle persistently infected with Leptospira borgpetersenii serovar Hardjo. Vaccination reduces urinary shedding of Leptospira borgpetersenii serovar Hardjo without clearance of renal colonisation. This effect appears 4 weeks post vaccination and its duration is unknown. The epidemiological significance of the reduced shedding has not been demonstrated. The vaccination may not prevent abortion in cows in which placental infection has already occurred. Dosage & Administration • Dose 2 ml • Administration By subcutaneous injection, preferably in the neck. • Shake the container well before withdrawing the dose. Basic vaccination scheme • 2 doses of vaccine separated by a 4 to 6 week interval. • Calves as young as 4 weeks of age may be vaccinated. Revaccination scheme • A single 2 ml dose on an annual basis. Withdrawals Zero days. Vaccinated cattle may be positive for diagnostic tests for leptospirosis and therefore unacceptable for export to some countries.

For active immunisation of cattle to prevent kidney colonisation and shedding of Leptospira borgpetersenii serovar Hardjo in urine. A 3 week onset of immunity and 12 month duration of protection has been demonstrated by challenge with Leptospira borgpetersenii serovar Hardjo. For active immunisation of cattle persistently infected with Leptospira borgpetersenii serovar Hardjo. Vaccination reduces urinary shedding of Leptospira borgpetersenii serovar Hardjo without clearance of renal colonisation. This effect appears 4 weeks post vaccination and its duration is unknown. The epidemiological significance of the reduced shedding has not been demonstrated. The vaccination may not prevent abortion in cows in which placental infection has already occurred. Dosage & Administration • Dose 2 ml • Administration By subcutaneous injection, preferably in the neck. • Shake the container well before withdrawing the dose. Basic vaccination scheme • 2 doses of vaccine separated by a 4 to 6 week interval. • Calves as young as 4 weeks of age may be vaccinated. Revaccination scheme • A single 2 ml dose on an annual basis. Withdrawals Zero days. Vaccinated cattle may be positive for diagnostic tests for leptospirosis and therefore unacceptable for export to some countries.

This vaccine only has a 5-7 days shelf life, please bear this in mind when ordering. For the active immunisation of susceptible breeding female sheep to reduce the effects of infection by Toxoplasma gondii, namely early embryonic death, barrenness and abortion. Vaccination with Toxovax is known to protect for at least two lambing seasons. Dosage & Administration Dose: 2 ml by intramuscular injection. Basic vaccination • Animals should be given a single dose at least 3 weeks prior to mating. • Ewe lambs, where it is intended to breed from them, may be vaccinated from 5 months of age. • Shearlings and older ewes should be vaccinated during the 4 month period prior to mating. Re-vaccination • After 2 years, a single dose at least 3 weeks prior to mating. Withdrawals Meat: 42 days.

This vaccine only has a 5-7 days shelf life, please bear this in mind when ordering. For the active immunisation of susceptible breeding female sheep to reduce the effects of infection by Toxoplasma gondii, namely early embryonic death, barrenness and abortion. Vaccination with Toxovax is known to protect for at least two lambing seasons. Dosage & Administration Dose: 2 ml by intramuscular injection. Basic vaccination • Animals should be given a single dose at least 3 weeks prior to mating. • Ewe lambs, where it is intended to breed from them, may be vaccinated from 5 months of age. • Shearlings and older ewes should be vaccinated during the 4 month period prior to mating. Re-vaccination • After 2 years, a single dose at least 3 weeks prior to mating. Withdrawals Meat: 42 days.