Cattle & Sheep Vaccines

For the active immunisation of cattle in order to induce serological and colostral antibody production against Salmonella dublin and Salmonella typhimurium and in the face of an outbreak to reduce Salmonella typhimurium infections when used under field conditions as part of an overall herd management programme. Bovivac S may also contribute to reducing S. typhimurium contamination of the environment. Dosage & Administration • Calves up to 6 months of age - 2 ml • Adult cattle - 5 ml

For the active immunisation of sheep and cattle against diseases caused by Clostridium perfringens type A; C. perfringens type B; C. perfringens type C; C. perfringens type D; C. chauvoei; C. novyi type B; C. septicum; C. sordellii; C. haemolyticum and against tetanus caused by C. tetani. For the passive immunisation of lambs and calves against infection caused by the above mentioned clostridial species (except C. haemolyticum in sheep). The onset of immunity is two weeks after the primary course. Dosage & Administration • Sheep From 2 weeks of age: Dose - 1 ml • Cattle From 2 weeks of age: Dose - 2 ml

For the active immunisation of sheep and cattle against diseases caused by Clostridium perfringens type A; C. perfringens type B; C. perfringens type C; C. perfringens type D; C. chauvoei; C. novyi type B; C. septicum; C. sordellii; C. haemolyticum and against tetanus caused by C. tetani. For the passive immunisation of lambs and calves against infection caused by the above mentioned clostridial species (except C. haemolyticum in sheep). The onset of immunity is two weeks after the primary course. Dosage & Administration • Sheep From 2 weeks of age: Dose - 1 ml • Cattle From 2 weeks of age: Dose - 2 ml

For the active immunisation of sheep and cattle against diseases associated with infections caused by Clostridium perfringens type A, C.perfringens type B, C.perfringens type C, C.perfringens type D, Clostridium chauvoei, Clostridium novyi type B, Clostridium septicum, Clostridium sordellii and Clostridium haemolyticum and against tetanus caused by Clostridium tetani. For the passive immunisation of lambs and calves against infections caused by the above mentioned clostridial species (except C.haemolyticum in sheep). The on Dosage & Administration • Sheep - from 2 weeks of age - 1 ml • Cattle - from 2 weeks of age - 2 ml • Primary vaccination: Two doses should be administered, 4-6 weeks apart. • Booster vaccination: A single dose should be administered at 6 to 12 month intervals.set of immunity is two weeks after the primary course.

For the active immunisation of sheep and cattle against diseases associated with infections caused by Clostridium perfringens type A, C.perfringens type B, C.perfringens type C, C.perfringens type D, Clostridium chauvoei, Clostridium novyi type B, Clostridium septicum, Clostridium sordellii and Clostridium haemolyticum and against tetanus caused by Clostridium tetani. For the passive immunisation of lambs and calves against infections caused by the above mentioned clostridial species (except C.haemolyticum in sheep). The on Dosage & Administration • Sheep - from 2 weeks of age - 1 ml • Cattle - from 2 weeks of age - 2 ml • Primary vaccination: Two doses should be administered, 4-6 weeks apart. • Booster vaccination: A single dose should be administered at 6 to 12 month intervals.set of immunity is two weeks after the primary course.

For the active immunisation of susceptible female breeding sheep to reduce abortion caused by Chlamydophila abortus infection. Dosage & Administration • Dose: 2 ml of reconstituted vaccine by intramuscular or subcutaneous injection. • Ewe lambs, where it is intended to breed from them, may be vaccinated from 5 months of age. • Shearlings and older ewes should be vaccinated during the 4 month period prior to mating. • Vaccination must take place at least 4 weeks before mating. Withdrawals: Meat: 7 days.

For the active immunisation of susceptible female breeding sheep to reduce abortion caused by Chlamydophila abortus infection. Dosage & Administration • Dose: 2 ml of reconstituted vaccine by intramuscular or subcutaneous injection. • Ewe lambs, where it is intended to breed from them, may be vaccinated from 5 months of age. • Shearlings and older ewes should be vaccinated during the 4 month period prior to mating. • Vaccination must take place at least 4 weeks before mating. Withdrawals: Meat: 7 days.

For the active immunisation of sheep as an aid to the prevention of footrot and reduction of lesions of footrot caused by serotypes of D. nodosus. Dosage & Administration Dose: 1 ml Administration: Initial Course: • Two doses, 6 weeks apart by subcutaneous injection. • The site for injection is on the side of the neck 2 - 3 inches behind the ear. • Thoroughly shake the vaccine before use. • As the vaccine contains an oil adjuvant it is rather viscous. It will aid administration in cold weather if the vaccine is gently warmed by immersion in warm water (not hot) for 3 - 4 minutes before use. • Syringes and needles should be sterilised before use and the injection made through an area of clean, dry skin, taking strict precautions against contamination in order to reduce the possibility of abscess formation. Vaccination programmes • These should be tailored to meet individual flock requirements which will vary from season to season according to the actual or likely incidence of footrot. • Wherever possible ‘whole flock’ vaccination programmes should be adopted. By this means disease incidence in the flock will decline and subsequent disease risk from the environment will be greatly reduced. Prevention programme • Commence vaccination with a single dose of vaccine. • Further doses of vaccine will be required according to the flock disease status and/or the climatic conditions. • If, after 4 - 6 weeks significant levels of disease remain in the flock or climatic conditions conducive to footrot persist, administer a further dose. Otherwise delay this dose until conditions favour re-emergence of the disease. • Subsequent doses should also be administered according to prevailing conditions. Thus, with severe and constant disease challenge, revaccination may be necessary at 4 - 5 monthly intervals; conversely under favourable conditions revaccination may be delayed until the incidence of disease challenge increases or climatic conditions worsen. • It should be noted that these adverse conditions tend to occur in the UK between March and May and between October and December thus, vaccination should normally be completed shortly before these periods if problems are anticipated. Treatment programme • A single dose of vaccine should be given to the flock immediately the disease becomes apparent. • For maximum effect, treatment with Footvax should be combined with the use of a footbath and antibiotic treatment. Revaccination: • should be as stated in the prevention programme, which should then be continued on the farm as the key element of the overall flock foot care programme.

For the active immunisation of sheep as an aid to the prevention of footrot and reduction of lesions of footrot caused by serotypes of D. nodosus. Dosage & Administration Dose: 1 ml Administration: Initial Course: • Two doses, 6 weeks apart by subcutaneous injection. • The site for injection is on the side of the neck 2 - 3 inches behind the ear. • Thoroughly shake the vaccine before use. • As the vaccine contains an oil adjuvant it is rather viscous. It will aid administration in cold weather if the vaccine is gently warmed by immersion in warm water (not hot) for 3 - 4 minutes before use. • Syringes and needles should be sterilised before use and the injection made through an area of clean, dry skin, taking strict precautions against contamination in order to reduce the possibility of abscess formation. Vaccination programmes • These should be tailored to meet individual flock requirements which will vary from season to season according to the actual or likely incidence of footrot. • Wherever possible ‘whole flock’ vaccination programmes should be adopted. By this means disease incidence in the flock will decline and subsequent disease risk from the environment will be greatly reduced. Prevention programme • Commence vaccination with a single dose of vaccine. • Further doses of vaccine will be required according to the flock disease status and/or the climatic conditions. • If, after 4 - 6 weeks significant levels of disease remain in the flock or climatic conditions conducive to footrot persist, administer a further dose. Otherwise delay this dose until conditions favour re-emergence of the disease. • Subsequent doses should also be administered according to prevailing conditions. Thus, with severe and constant disease challenge, revaccination may be necessary at 4 - 5 monthly intervals; conversely under favourable conditions revaccination may be delayed until the incidence of disease challenge increases or climatic conditions worsen. • It should be noted that these adverse conditions tend to occur in the UK between March and May and between October and December thus, vaccination should normally be completed shortly before these periods if problems are anticipated. Treatment programme • A single dose of vaccine should be given to the flock immediately the disease becomes apparent. • For maximum effect, treatment with Footvax should be combined with the use of a footbath and antibiotic treatment. Revaccination: • should be as stated in the prevention programme, which should then be continued on the farm as the key element of the overall flock foot care programme.

For the active immunisation of sheep as an aid to the prevention of footrot and reduction of lesions of footrot caused by serotypes of D. nodosus. Dosage & Administration Dose: 1 ml Administration: Initial Course: • Two doses, 6 weeks apart by subcutaneous injection. • The site for injection is on the side of the neck 2 - 3 inches behind the ear. • Thoroughly shake the vaccine before use. • As the vaccine contains an oil adjuvant it is rather viscous. It will aid administration in cold weather if the vaccine is gently warmed by immersion in warm water (not hot) for 3 - 4 minutes before use. • Syringes and needles should be sterilised before use and the injection made through an area of clean, dry skin, taking strict precautions against contamination in order to reduce the possibility of abscess formation. Vaccination programmes • These should be tailored to meet individual flock requirements which will vary from season to season according to the actual or likely incidence of footrot. • Wherever possible ‘whole flock’ vaccination programmes should be adopted. By this means disease incidence in the flock will decline and subsequent disease risk from the environment will be greatly reduced. Prevention programme • Commence vaccination with a single dose of vaccine. • Further doses of vaccine will be required according to the flock disease status and/or the climatic conditions. • If, after 4 - 6 weeks significant levels of disease remain in the flock or climatic conditions conducive to footrot persist, administer a further dose. Otherwise delay this dose until conditions favour re-emergence of the disease. • Subsequent doses should also be administered according to prevailing conditions. Thus, with severe and constant disease challenge, revaccination may be necessary at 4 - 5 monthly intervals; conversely under favourable conditions revaccination may be delayed until the incidence of disease challenge increases or climatic conditions worsen. • It should be noted that these adverse conditions tend to occur in the UK between March and May and between October and December thus, vaccination should normally be completed shortly before these periods if problems are anticipated. Treatment programme • A single dose of vaccine should be given to the flock immediately the disease becomes apparent. • For maximum effect, treatment with Footvax should be combined with the use of a footbath and antibiotic treatment. Revaccination: • should be as stated in the prevention programme, which should then be continued on the farm as the key element of the overall flock foot care programme.

Combined 7 in 1 Clostridial plus Pasteurella vaccine containing per ml: Clostridium perfringens beta toxoid : Clostridium perfringens epsilon toxoid ; Clostridium septicum: Clostridium tetani toxoid: Clostridium novyi toxoid ; Clostridium chauvoei cells and equivalent toxoid and formalin killed cells of the epidemiologically most important serotypes of Mannheimia haemolytica and Pasteurella trehalosi. For the active immunisation of sheep as an aid in the control of lamb dysentery, pulpy kidney, struck, tetanus, braxy, blackleg, black disease and clostridial metritis caused by the above listed organisms. The vaccine may be used as an aid in the control of pneumonic pasteurellosis in sheep of all ages from a minimum age of 3 weeks and in the control of systemic pasteurellosis in weaned fattening and breeding sheep. Dosage & Administration • Sheep of all ages: 2 ml per injection by subcutaneous injection in the lateral side of the upper neck observing aseptic precautions. • All breeding sheep not previously vaccinated with Heptavac P Plus must receive two injections, each of 2 ml, separated by an interval of 4-6 weeks. • Thereafter they must receive booster injections at intervals of not more than 12 months. • In adult breeding ewes these yearly booster injections should be given during the pre-lambing period, 4-6 weeks before lambing, as an aid in control of disease in their lambs. • Ewes may be vaccinated during pregnancy as an aid in the control of lamb dysentery, pulpy kidney, tetanus and pasteurellosis in their lambs provided that the lambs receive sufficient immune colostrum during the first 1-2 days of life. • On farms where the incidence of pasteurellosis is high, a supplementary booster injection using a Pasteurella vaccine may be required 2-3 weeks prior to expected seasonal outbreaks. • Heptavac P Plus should not be used in lambs less than 3 weeks of age due to the possible immunological incompetence of the very young lamb and competition from any maternally derived colostral antibodies. • Lambs being retained for fattening or subsequent breeding will require a full course of vaccination. At a minimum age of 3 weeks these lambs should receive two injections, each of 2.0 ml, separated by an interval of 4-6 weeks. • It should be noted that Heptavac P Plus is the recommended vaccine for breeding stock since it provides optimal aid in the control of the predominant clostridial diseases in adult sheep by active immunisation and in young lambs by passive immunisation.

Combined 7 in 1 Clostridial plus Pasteurella vaccine containing per ml: Clostridium perfringens beta toxoid : Clostridium perfringens epsilon toxoid ; Clostridium septicum: Clostridium tetani toxoid: Clostridium novyi toxoid ; Clostridium chauvoei cells and equivalent toxoid and formalin killed cells of the epidemiologically most important serotypes of Mannheimia haemolytica and Pasteurella trehalosi. For the active immunisation of sheep as an aid in the control of lamb dysentery, pulpy kidney, struck, tetanus, braxy, blackleg, black disease and clostridial metritis caused by the above listed organisms. The vaccine may be used as an aid in the control of pneumonic pasteurellosis in sheep of all ages from a minimum age of 3 weeks and in the control of systemic pasteurellosis in weaned fattening and breeding sheep. Dosage & Administration • Sheep of all ages: 2 ml per injection by subcutaneous injection in the lateral side of the upper neck observing aseptic precautions. • All breeding sheep not previously vaccinated with Heptavac P Plus must receive two injections, each of 2 ml, separated by an interval of 4-6 weeks. • Thereafter they must receive booster injections at intervals of not more than 12 months. • In adult breeding ewes these yearly booster injections should be given during the pre-lambing period, 4-6 weeks before lambing, as an aid in control of disease in their lambs. • Ewes may be vaccinated during pregnancy as an aid in the control of lamb dysentery, pulpy kidney, tetanus and pasteurellosis in their lambs provided that the lambs receive sufficient immune colostrum during the first 1-2 days of life. • On farms where the incidence of pasteurellosis is high, a supplementary booster injection using a Pasteurella vaccine may be required 2-3 weeks prior to expected seasonal outbreaks. • Heptavac P Plus should not be used in lambs less than 3 weeks of age due to the possible immunological incompetence of the very young lamb and competition from any maternally derived colostral antibodies. • Lambs being retained for fattening or subsequent breeding will require a full course of vaccination. At a minimum age of 3 weeks these lambs should receive two injections, each of 2.0 ml, separated by an interval of 4-6 weeks. • It should be noted that Heptavac P Plus is the recommended vaccine for breeding stock since it provides optimal aid in the control of the predominant clostridial diseases in adult sheep by active immunisation and in young lambs by passive immunisation.