Cattle & Sheep Vaccines

For the active immunisation of sheep and cattle to reduce mortality and clinical signs of blackleg disease caused by clostridium chauvoei. Active ingredient: Clostridium chauvoei

For active immunisation of cattle in the absence of maternally derived antibodies against: • parainfluenza 3 virus, to reduce virus excretion due to infection • bovine respiratory syncytial virus, to reduce virus excretion due to infection • Mannheimia haemolytica serotype A1, to reduce clinical signs and lung lesions. Onset of immunity (demonstrated by challenge): • 3 weeks after primary vaccination • Duration of immunity (demonstrated by challenge): 6 months after primary vaccination Dosage & Administration 2 ml to be administered subcutaneously. Primary vaccination • Calves can be vaccinated from 2 weeks of age. • Calves from non-immune dams: 2 injections 3 weeks apart from 2 weeks of age Where the immune status of the dam is unknown, the vaccine scheme should be adapted at the discretion of the veterinarian. Revaccination Administer a single dose 6 months after completion of the primary vaccination scheme. Withdrawals: Zero day

For active immunisation of cattle in the absence of maternally derived antibodies against: • parainfluenza 3 virus, to reduce virus excretion due to infection • bovine respiratory syncytial virus, to reduce virus excretion due to infection • Mannheimia haemolytica serotype A1, to reduce clinical signs and lung lesions. Onset of immunity (demonstrated by challenge): • 3 weeks after primary vaccination • Duration of immunity (demonstrated by challenge): 6 months after primary vaccination Dosage & Administration 2 ml to be administered subcutaneously. Primary vaccination • Calves can be vaccinated from 2 weeks of age. • Calves from non-immune dams: 2 injections 3 weeks apart from 2 weeks of age Where the immune status of the dam is unknown, the vaccine scheme should be adapted at the discretion of the veterinarian. Revaccination Administer a single dose 6 months after completion of the primary vaccination scheme. Withdrawals: Zero day

For active immunisation of cattle in the absence of maternally derived antibodies against: • parainfluenza 3 virus, to reduce virus excretion due to infection • bovine respiratory syncytial virus, to reduce virus excretion due to infection • bovine viral diarrhoea virus, to reduce virus excretion due to infection • Mannheimia haemolytica serotype A1, to reduce clinical signs and lung lesions. Onset of immunity (demonstrated by challenge): • 3 weeks after primary vaccination • Duration of immunity (demonstrated by challenge): 6 months after primary vaccination Dosage & Administration 2 ml to be administered subcutaneously. Primary vaccination • Calves can be vaccinated from 2 weeks of age. • Calves from non-immune dams: 2 injections 3 weeks apart from 2 weeks of age Where the immune status of the dam is unknown, the vaccine scheme should be adapted at the discretion of the veterinarian. Revaccination Administer a single dose 6 months after completion of the primary vaccination scheme. Withdrawals: Zero days

For active immunisation of cattle in the absence of maternally derived antibodies against: • parainfluenza 3 virus, to reduce virus excretion due to infection • bovine respiratory syncytial virus, to reduce virus excretion due to infection • bovine viral diarrhoea virus, to reduce virus excretion due to infection • Mannheimia haemolytica serotype A1, to reduce clinical signs and lung lesions. Onset of immunity (demonstrated by challenge): • 3 weeks after primary vaccination • Duration of immunity (demonstrated by challenge): 6 months after primary vaccination Dosage & Administration 2 ml to be administered subcutaneously. Primary vaccination • Calves can be vaccinated from 2 weeks of age. • Calves from non-immune dams: 2 injections 3 weeks apart from 2 weeks of age Where the immune status of the dam is unknown, the vaccine scheme should be adapted at the discretion of the veterinarian. Revaccination Administer a single dose 6 months after completion of the primary vaccination scheme. Withdrawals: Zero days

For the active immunisation of calves from the age of 10days against bovine respiratory syncytial virus (BRSV) and bovine parainfluenza 3 virus (PI3V), to reduce the quality and duration of nasal excretion of both viruses. Onset of immunity - 10days after vaccine Duration of immunity - 12 weeks after vaccination Dosage & Administration Administer one dose (2ml) of the reconstituted vaccine intranasally (1ml of the vaccine per nostril) to calves from 10days of age using an intranasal applicator. Withdrawals: Zero days

For active immunisation of cattle from 3 months of age to reduce hyperthermia and to minimise the reduction of leukocyte count caused by bovine viral diarrhoea virus (BVDV-1 and BVDV-2), and to reduce virus shedding and viraemia caused by BVDV-2. For active immunisation of cattle against BVDV-1 and BVDV-2, to prevent the birth of persistently infected calves caused by transplacental infection. Onset of immunity: 3 weeks after immunisation. Duration of immunity: 1 year. Dosage & Administration Primary vaccination: After reconstitution, administer one dose (2 ml) of the vaccine by intramuscular (IM) injection. It is recommended to vaccinate cattle at least 3 weeks before insemination/mating to provide foetal protection from the first day of conception. Animals which are vaccinated later than 3 weeks before gestation or during the early gestation may not be protected against foetal infection. This should be considered in case of herd vaccination. Recomended re-vaccination programme: Revaccination is recommended after 1 year. 12 months after primary vaccination most studied animals still had antibody titres at plateau while some animals had lower titres. Withdrawals: Zero days

For active immunisation of cattle from 3 months of age to reduce hyperthermia and to minimise the reduction of leukocyte count caused by bovine viral diarrhoea virus (BVDV-1 and BVDV-2), and to reduce virus shedding and viraemia caused by BVDV-2. For active immunisation of cattle against BVDV-1 and BVDV-2, to prevent the birth of persistently infected calves caused by transplacental infection. Onset of immunity: 3 weeks after immunisation. Duration of immunity: 1 year. Dosage & Administration Primary vaccination: After reconstitution, administer one dose (2 ml) of the vaccine by intramuscular (IM) injection. It is recommended to vaccinate cattle at least 3 weeks before insemination/mating to provide foetal protection from the first day of conception. Animals which are vaccinated later than 3 weeks before gestation or during the early gestation may not be protected against foetal infection. This should be considered in case of herd vaccination. Recomended re-vaccination programme: Revaccination is recommended after 1 year. 12 months after primary vaccination most studied animals still had antibody titres at plateau while some animals had lower titres. Withdrawals: Zero days

For active immunisation of cattle from 3 months of age to reduce hyperthermia and to minimise the reduction of leukocyte count caused by bovine viral diarrhoea virus (BVDV-1 and BVDV-2), and to reduce virus shedding and viraemia caused by BVDV-2. For active immunisation of cattle against BVDV-1 and BVDV-2, to prevent the birth of persistently infected calves caused by transplacental infection. Onset of immunity: 3 weeks after immunisation. Duration of immunity: 1 year. Dosage & Administration Primary vaccination: After reconstitution, administer one dose (2 ml) of the vaccine by intramuscular (IM) injection. It is recommended to vaccinate cattle at least 3 weeks before insemination/mating to provide foetal protection from the first day of conception. Animals which are vaccinated later than 3 weeks before gestation or during the early gestation may not be protected against foetal infection. This should be considered in case of herd vaccination. Recomended re-vaccination programme: Revaccination is recommended after 1 year. 12 months after primary vaccination most studied animals still had antibody titres at plateau while some animals had lower titres. Withdrawals: Zero days

For the active immunisation of pregnant cows and heifers to raise antibodies against E. coli adhesion F5 (K 99) antigen, rotavirus and coronavirus. When calves are fed colostrum from vaccinated cows during the first week of life, these antibodies have been demonstrated to reduce the severity of diarrhoea caused by bovine rotavirus, bovine coronavirus and enteropathogenic E. coli F5 (K99) and to reduce the shedding of virus by calves infected with bovine rotavirus or bovine coronavirus. Onset of immunity: Passive immunity commences with colostrum feeding and is dependent on calves receiving sufficient colostrum after birth. Dosage & Administration One dose: 3 ml intramuscular One dose in the course of each pregnancy, given in the 12 - 3 week period before calving is expected.

For the active immunisation of pregnant cows and heifers to raise antibodies against E. coli adhesion F5 (K 99) antigen, rotavirus and coronavirus. When calves are fed colostrum from vaccinated cows during the first week of life, these antibodies have been demonstrated to reduce the severity of diarrhoea caused by bovine rotavirus, bovine coronavirus and enteropathogenic E. coli F5 (K99) and to reduce the shedding of virus by calves infected with bovine rotavirus or bovine coronavirus. Onset of immunity: Passive immunity commences with colostrum feeding and is dependent on calves receiving sufficient colostrum after birth. Dosage & Administration One dose: 3 ml intramuscular One dose in the course of each pregnancy, given in the 12 - 3 week period before calving is expected.

For active immunisation of cows and heifers from eight months of age onwards to protect the foetus against transplacental infection with Bovine Viral Diarrhoea virus. Dosage & Administration Before using the vaccine allow it to reach ambient temperature (15-25°C). Shake well before use. Use sterile syringes and needles, or Sterimatic products. Intramuscular injection. 2 ml per animal. All cattle can be vaccinated from an age of eight months onwards. Can be used during pregnancy. Foetal protection can be expected if the primary immunisation has been finalised 4 weeks before start of the gestation. Animals which are vaccinated less than 4 weeks before gestation or during the early gestation will not be protected against foetal infection. Individual vaccination Basic immunisation • Two vaccinations with an interval of 4 weeks. • The second vaccination should be given not later than 4 weeks before the start of the gestation. • Revaccination One vaccination 4 weeks before start of the next gestation. Herd vaccination Basic immunisation • Two vaccinations with an interval of 4 weeks. • For use in cattle from eight months of age, all animals should be vaccinated. Revaccination • One vaccination every 6 months