Pig & Poultry Vaccines

For active immunisation of broiler chickens and future layer/breeders in order to reduce mortality and lesions (pericarditis, perihepatitis, airsacculitis) associated with Escherichia coli serotype O78.

For active immunisation of breeding females from farms affected with European (genotype 1) Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) to reduce the duration of viraemia, the proportion of viraemic gilts/sows and viral loads in blood after exposure to PRRSV as shown under experimental conditions. Onset of immunity : 4 weeks Duration of immunity :17 weeks Vaccination of breeding females according to the recommended schedule described below reduces the negative reproductive disorders associated with PRRSV. Under experimental challenge conditions a reduction in transplacental virus transmission after challenge was additionally demonstrated. In piglets from vaccinated sows, a reduction in the negative impact of PRRS virus infection (mortality, clinical signs and weight gain) was also demonstrated during the first 20 days of life. Dosage and administration Single intramuscular injection of one dose (2 ml), irrespective of body weight. For reconstitution, transfer the entire content of the solvent vial to the vial containing the lyophilisate and reconstitute the lyophilisate as follows: 10 doses in 20 ml, 50 doses in 100 ml and 100 doses in 200 ml of the solvent. Ensure that the lyophilisate is completely reconstituted before use. Visual appearance after reconstitution: clear, colourless suspension. Avoid introduction of contamination during use. Use sterile equipment. Avoid multiple broaching, for example by using automatic injectors. Regime of vaccination: Gilts: for protection against PRRSV during pregnancy vaccination is recommended before integration into the sow herd between 2 and 5 weeks prior to breeding. Gilts can then be subjected to the same vaccination programme as the sow herd. Sows: mass vaccination is recommended in a whole herd programme, in which all the pregnant and non-pregnant sows in the herd are vaccinated every three to four months.

For active immunisation of breeding females from farms affected with European (genotype 1) Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) to reduce the duration of viraemia, the proportion of viraemic gilts/sows and viral loads in blood after exposure to PRRSV as shown under experimental conditions. Onset of immunity : 4 weeks Duration of immunity :17 weeks Vaccination of breeding females according to the recommended schedule described below reduces the negative reproductive disorders associated with PRRSV. Under experimental challenge conditions a reduction in transplacental virus transmission after challenge was additionally demonstrated. In piglets from vaccinated sows, a reduction in the negative impact of PRRS virus infection (mortality, clinical signs and weight gain) was also demonstrated during the first 20 days of life. Dosage and administration Single intramuscular injection of one dose (2 ml), irrespective of body weight. For reconstitution, transfer the entire content of the solvent vial to the vial containing the lyophilisate and reconstitute the lyophilisate as follows: 10 doses in 20 ml, 50 doses in 100 ml and 100 doses in 200 ml of the solvent. Ensure that the lyophilisate is completely reconstituted before use. Visual appearance after reconstitution: clear, colourless suspension. Avoid introduction of contamination during use. Use sterile equipment. Avoid multiple broaching, for example by using automatic injectors. Regime of vaccination: Gilts: for protection against PRRSV during pregnancy vaccination is recommended before integration into the sow herd between 2 and 5 weeks prior to breeding. Gilts can then be subjected to the same vaccination programme as the sow herd. Sows: mass vaccination is recommended in a whole herd programme, in which all the pregnant and non-pregnant sows in the herd are vaccinated every three to four months.

Active immunisation of pigs from the age of 56 days onwards including pregnant sows against swine influenza caused by subtypes H1N1, H3N2 and H1N2 to reduce clinical signs and viral lung load after infection. Onset of immunity: 7 days after primary vaccination. Duration of immunity: 4 months in pigs vaccinated between the age of 56 and 96 days and 6 months in pigs vaccinated for the first time at 96 days and above. Active immunisation of pregnant sows after finished primary immunisation by administration of a single dose 14 days prior to farrowing to develop high colostral immunity which provides clinical protection of piglets for at least 33 days after birth. For intramuscular use. PIGLETS: Primary vaccination: 2 injections of one dose (2 ml) - From the age of 96 days, with an interval of 3 weeks between injections to achieve duration of immunity over 6 months. or - Between the age of 56 and 96 days, with an interval of 3 weeks between injections to achieve duration of immunity over 4 months. GILTS AND SOWS: Primary vaccination: see above A booster is possible at each stage of pregnancy and lactation. When vaccination is performed 14 days prior to farrowing with one dose (2 ml), it provides maternally-derived immunity to the piglets which protects them from clinical signs of influenza at least until day 33 after birth. Maternally-derived immunity in the piglets interacts with antibody induction. Generally, maternally-derived antibodies induced by vaccination last for approx. 5-8 weeks after birth. In particular cases of multiple contacts of the sows with antigens (field infections + vaccination) the antibodies transmitted to the piglets may last until week 12 of life. In the latter case piglets should be vaccinated after the age of 96 days.

Active immunisation of pigs from the age of 8 weeks onwards against pandemic H1N1 porcine influenza virus to reduce viral lung load and viral excretion. Onset of immunity: 7 days after primary vaccination. Duration of immunity: 3 months after primary vaccination For intramuscular use. Vaccination: 2 injections of one dose (1 ml) from the age of 56 days, with an interval of 3 weeks between injections. The efficacy of revaccination has not been investigated and therefore no revaccination schedule is proposed. Maternally-derived antibodies in piglets interfere with the RESPIPORC FLUpan H1N1 mediated immunity. Generally, maternally-derived antibodies induced by vaccination last for approximately 5–8 weeks after birth. In cases of exposure of the sows to antigens (from either field infections and/or vaccination) the antibodies transmitted to the piglets can interfere with active immunisation at 12 weeks of age. In such cases the piglets should be vaccinated after the age of 12 weeks.

For active immunisation of pregnant sows and gilts against rotaviral and enteral coliinfections, to induce colostral and lactogenous immunity in newborn piglets. Piglets are protected against antigens included in vaccine during suckling from vaccinated mothers. Dosage, application and vaccination scheme Dose - 2 ml, intramuscularly. Prime vaccination: Sows and gilts - administration of 2 doses within an interval of 2 to 4 weeks; the second dose at the latest 2 weeks prior to the expected farrowing. Revaccination: Administration of 1 dose (2 ml) 4 to 2 weeks prior to each expected farrowing.

Piglets: For the passive protection of neonatal piglets by means of the active immunisation of breeding sows and gilts to reduce mortality and clinical signs of neonatal enterotoxicosis, such as diarrhoea caused by enterotoxigenic Escherichia coli, which express F4ab (K88ab), F4ac (K88ac), F5 (K99) or F6 (987P) adhesins. The persistence of these antibodies has not been established. For the passive immunisation of neonatal piglets against Necrotic Enteritis by means of the active immunisation of breeding sows and gilts to induce seroneutralizing antibodies against the ?-toxin of Clostridium perfringens type C . The persistance of antibodies has not been established Sows and gilts: For active immunisation of breeding sows and gilts to induce seroneutralizing antibodies against ?-toxin of Clostridium novyi. The relevance of the seroneutralizing antibodies was not experimentally determined. Antibodies have been detected 3 weeks after vaccinaton. The persistence of these antibodies has not been established.

Active immunisation of pigs from six weeks of age for the reduction of mortality, clinical symptoms and lung lesions caused by Actinobacillus pleuropneumoniae serotypes 2 and 9 infections. Onset of immunity: 3 weeks after the primary vaccination. Duration of immunity: 22 weeks following second vaccination.

For the active immunisation of pigs of a minimum age of 21 days to reduce lung lesions that are caused by Mycoplasma hyopneumoniae.

Onset of immunity: 4 weeks following vaccination.

Duration of immunity: 6 months.

Dosage & Administration:
One dose of 2.0 ml per animal should be administered intramuscularly in the neck to pigs from the age of 21 days onwards.

For active immunisation of future breeder turkeys: -As booster vaccination after priming with live vaccines against Newcastle Disease and Turkey Rhinotracheitis to reduce mortality and clinical signs of Newcastle Disease and to induce a specific seroconversion against Newcastle Disease and Turkey Rhinotracheitis in vaccinated birds throughout the laying period. -As vaccination against Paramyxovirus Type 3 to reduce the decrease in egg production, as demonstrated by challenge at peak lay, and to induce a specific seroconversion against Paramyxovirus Type 3 throughout the laying period. Onset of immunity: 4 weeks after the first injection. Duration of immunity: one laying period (demonstrated by serology). Contra-indications

Live attenuated porcine reproductive and respiratory syndrome virus (PRRSV), strain VP-046 BIS: 103.5-105.5 CCID50. INDICATIONS: Sows: Active immunisation of breeding females from pig farms affected by European PRRS virus in order to reduce reproductive disorders. The vaccination reduced the negative impact of PRRS virus infection on piglet performance (mortality and weight gain) within the first 28 days of life. Piglets: Active immunisation of pig farms affected by European PRRS virus in order to reduce the clinical signs associated with PRRS virus infection, the incidence and duration of viremia, as well as the duration of the spread of the virus by infected animals. In field conditions, there was a reduction in the death rate, as well as a daily weight gain in the negative effects of infection. ADMINISTRATION ROUTE: Intramuscular (IM) or intradermal (ID). IM route: administer in the neck muscles. ID route: administer preferably in the neck area and with the proper injection device DOSAGE: 2 ml/animal by IM route; or 0.2 ml/animal by ID route. In general, the following standard vaccination programme is recommended: Gilts: Vaccinate 4 weeks before mating. Sows: Vaccinate 2 weeks before mating or at 8-9 weeks of gestation. Piglets: Vaccinate beginning at 4 weeks. For maximum control of the PRRS virus, a large-scale vaccination of all animals from an early age onwards is recommended. WITHDRAWAL TIME: 0 days.

Live attenuated porcine reproductive and respiratory syndrome virus (PRRSV), strain VP-046 BIS: 103.5-105.5 CCID50. INDICATIONS: Sows: Active immunisation of breeding females from pig farms affected by European PRRS virus in order to reduce reproductive disorders. The vaccination reduced the negative impact of PRRS virus infection on piglet performance (mortality and weight gain) within the first 28 days of life. Piglets: Active immunisation of pig farms affected by European PRRS virus in order to reduce the clinical signs associated with PRRS virus infection, the incidence and duration of viremia, as well as the duration of the spread of the virus by infected animals. In field conditions, there was a reduction in the death rate, as well as a daily weight gain in the negative effects of infection. ADMINISTRATION ROUTE: Intramuscular (IM) or intradermal (ID). IM route: administer in the neck muscles. ID route: administer preferably in the neck area and with the proper injection device DOSAGE: 2 ml/animal by IM route; or 0.2 ml/animal by ID route. In general, the following standard vaccination programme is recommended: Gilts: Vaccinate 4 weeks before mating. Sows: Vaccinate 2 weeks before mating or at 8-9 weeks of gestation. Piglets: Vaccinate beginning at 4 weeks. For maximum control of the PRRS virus, a large-scale vaccination of all animals from an early age onwards is recommended. WITHDRAWAL TIME: 0 days.