Large Animal

Flunixin meglumine is a relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties. Flunixin Injection is indicated for use in cattle and horses in the alleviation of inflammation and pain. Horses: Flunixin Injection is indicated for the alleviation of inflammatory signs associated with musculo-skeletal disorders and for the alleviation of visceral pain associated with colic. Cattle: Flunixin Injection is indicated for the control of acute inflammation associated with respiratory disease. Flunixin Injection has also been shown to have some benefit in the treatment of acute pulmonary emphysema (fog fever) and as adjunctive therapy in the treatment of acute mastitis. Pigs: Flunixin Injection is indicated as an adjunctive therapy in the treatment of swine respiratory diseases. Active ingredient: Flunixin Meglumine

Mepivacaine is indicated for infiltration, nerve block, intra-articular and epidural anaesthesia in horses. Active ingredient: Mepivacaine hydrochloride

Cattle: • alleviation of pain (e.g. from pressure trauma) resulting from parturient paresis; • reducing the pyrexia and distress associated with bacterial respiratory disease when used in conjunction with antimicrobial therapy as appropriate; • improving the recovery rate in acute clinical mastitis, including acute endotoxin mastitis, caused by gram negative micro-organisms, in conjunction with antimicrobial therapy; • alleviation of pain associated with udder oedema following calving. • reducing pain associated with lameness. • Pigs: • reducing the pyrexia and respiratory rate associated with bacterial or viral respiratory disease when used in conjunction with antimicrobial therapy as appropriate. • the supportive treatment of Mastitis Metritis Agalactia Syndrome in sows, in conjunction with antimicrobial therapy as appropriate. Dosage & Administration Cattle: • The recommended dose is 3mg ketoprofen/kg body weight, i.e. 1ml of the product/33kg body weight, administered by intravenous or deep intramuscular injection once daily for up to 3 days. Pigs: • The recommended dose is 3mg ketoprofen/kg body weight, i.e. 1ml of the product /33kg body weight, administered once by deep intramuscular injection Withdrawals Cattle: Meat & offal: • following intravenous administration - 1 day ; • following intramuscular administration - 4 days Milk: zero hours Pigs: Meat & offal: 4 days

Cattle: For use in acute respiratory infection with appropriate antibiotic therapy to reduce clinical signs in cattle. For use in diarrhoea in combination with oral re-hydration therapy to reduce clinical signs in calves of over one week of age and young, non-lactating cattle. For adjunctive therapy in the treatment of acute mastitis, in combination with antibiotic therapy.Pigs: For use in non-infectious locomotor disorders to reduce the symptoms of lameness and inflammation.For adjunctive therapy in the treatment of puerperal septicaemia and toxaemia (mastitis-metritis-agalactia syndrome) with appropriate antibiotic therapy. Horses: For use in the alleviation of inflammation and relief of pain in both acute and chronic musculo-skeletal disorders. For the relief of pain associated with equine colic. Active ingredient: Meloxicam

Cattle: For use in acute respiratory infection with appropriate antibiotic therapy to reduce clinical signs in cattle. For use in diarrhoea in combination with oral re-hydration therapy to reduce clinical signs in calves of over one week of age and young, non-lactating cattle. For adjunctive therapy in the treatment of acute mastitis, in combination with antibiotic therapy.Pigs: For use in non-infectious locomotor disorders to reduce the symptoms of lameness and inflammation.For adjunctive therapy in the treatment of puerperal septicaemia and toxaemia (mastitis-metritis-agalactia syndrome) with appropriate antibiotic therapy. Horses: For use in the alleviation of inflammation and relief of pain in both acute and chronic musculo-skeletal disorders. For the relief of pain associated with equine colic. Active ingredient: Meloxicam

Cattle: For use in acute respiratory infection with appropriate antibiotic therapy to reduce clinical signs in cattle. For use in diarrhoea in combination with oral re-hydration therapy to reduce clinical signs in calves of over one week of age and young, non-lactating cattle. For adjunctive therapy in the treatment of acute mastitis, in combination with antibiotic therapy.Pigs: For use in non-infectious locomotor disorders to reduce the symptoms of lameness and inflammation.For adjunctive therapy in the treatment of puerperal septicaemia and toxaemia (mastitis-metritis-agalactia syndrome) with appropriate antibiotic therapy. Horses: For use in the alleviation of inflammation and relief of pain in both acute and chronic musculo-skeletal disorders. For the relief of pain associated with equine colic. Active ingredient: Meloxicam

Meloxicam is a NSAID of the oxicam class which acts by inhibition of prostaglandin synthesis, thereby exerting anti-inflammatory, anti-exudative, analgesic and antipyretic effects. It reduces leukocyte infiltration into the inflamed tissue. Meloxidolor® is a clear yellow solution for injection containing 20 mg meloxicam per ml (and 150 mg of ethanol as preservative). Treatment for acute respiratory infection, diarrhoea, acute mastitis and dehorning pain in cattle; musculoskeletal disorders and colic pain relief in horses; and for acute non-infectious locomotor disorders in pigs and puerperal septicaemia and toxaemia in sows.

Cattle: For use in acute respiratory infection with appropriate antibiotic therapy to reduce clinical signs in cattle ~ For use in diarrhoea in combination with oral re-hydration therapy to reduce clinical signs in calves of over one week of age and young, non-lactating cattle~ For adjunctive therapy in the treatment of acute mastitis, in combination with antibiotic therapy ~ For the relief of post-operative pain following dehorning in calves. Pigs: For use in non-infectious locomotor disorders to reduce the symptoms of lameness and inflammation~ For adjunctive therapy in the treatment of puerperal septicaemia and toxaemia (mastitis–metritis–agalactia syndrome) with appropriate antibiotic therapy. Horses: For use in the alleviation of inflammation and relief of pain in both acute and chronic musculo-skeletal disorders~ For the relief of pain associated with equine colic.

Cattle: For use in acute respiratory infection with appropriate antibiotic therapy to reduce clinical signs in cattle ~ For use in diarrhoea in combination with oral re-hydration therapy to reduce clinical signs in calves of over one week of age and young, non-lactating cattle~ For adjunctive therapy in the treatment of acute mastitis, in combination with antibiotic therapy ~ For the relief of post-operative pain following dehorning in calves. Pigs: For use in non-infectious locomotor disorders to reduce the symptoms of lameness and inflammation~ For adjunctive therapy in the treatment of puerperal septicaemia and toxaemia (mastitis–metritis–agalactia syndrome) with appropriate antibiotic therapy. Horses: For use in the alleviation of inflammation and relief of pain in both acute and chronic musculo-skeletal disorders~ For the relief of pain associated with equine colic.

Metacam 20 mg/ml solution is a non-steroidal anti-inflammatory drug (NSAID) for use in cattle, pigs and horses. Metacam® 40 mg/ml solution for injection for cattle and horses. Cattle: • For use in acute respiratory infection with appropriate antibiotic therapy to reduce clinical signs in cattle. • For use in diarrhoea, in combination with oral rehydration therapy, to reduce clinical signs in calves of over one week of age and young non-lactating cattle. • For adjunctive therapy in the treatment of acute mastitis, in combination with antibiotic therapy. • For the relief of post-operative pain following dehorning in calves. Pigs • For use in non-infectious locomotor disorders to reduce the symptoms of lameness and inflammation. • For adjunctive therapy in the treatment of puerperal septicaemia and toxaemia (mastitis-metritis-agalactia syndrome) with appropriate antibiotic therapy. Horses • For use in the alleviation of inflammation and relief of pain in both acute and chronic musculo-skeletal disorders. • For the relief of pain associated with equine colic. Dosage & Administration of 20mg/ml Cattle: Single subcutaneous or intravenous injection at a dose rate of 0.5 mg meloxicam/kg bodyweight (i.e. 2.5 ml/100 kg bodyweight) in combination with antibiotic therapy or with oral rehydration therapy as appropriate. Pigs: Single intramuscular injection at a dosage of 0.4 mg meloxicam/kg bodyweight (i.e. 2.0ml/100kg bodyweight) in combination with antibiotic therapy, as appropriate. If required, a second administration of meloxicam can be given after 24 hours. Dosage & Administration of 40mg/ml Cattle: Single subcutaneous or intravenous injection at a dose of 0.5 mg meloxicam/kg body weight (i.e. 1.25 ml/100 kg body weight) in combination with antibiotic therapy or with oral re-hydration therapy, as appropriate. Horses: Single intravenous injection at a dose of 0.6 mg meloxicam/kg body weight (i.e. 1.5 ml/100 kg body weight). For use in the alleviation of inflammation and the relief of pain in both acute and chronic musculo-skeletal disorders, Metacam 15 mg/ml oral suspension may be used for continuation of treatment at a dose of 0.6 mg meloxicam/kg body weight, 24 hours after administration of the injection. Withdrawals: Cattle: Meat and offal - 15 days, Milk - 120 hours. Pigs: Meat and offal - 5 days. Horse meat and offal: 5 days. Not authorised for use in horses producing milk for human consumption.

Metacam 20 mg/ml solution is a non-steroidal anti-inflammatory drug (NSAID) for use in cattle, pigs and horses. Metacam® 40 mg/ml solution for injection for cattle and horses. Cattle: • For use in acute respiratory infection with appropriate antibiotic therapy to reduce clinical signs in cattle. • For use in diarrhoea, in combination with oral rehydration therapy, to reduce clinical signs in calves of over one week of age and young non-lactating cattle. • For adjunctive therapy in the treatment of acute mastitis, in combination with antibiotic therapy. • For the relief of post-operative pain following dehorning in calves. Pigs • For use in non-infectious locomotor disorders to reduce the symptoms of lameness and inflammation. • For adjunctive therapy in the treatment of puerperal septicaemia and toxaemia (mastitis-metritis-agalactia syndrome) with appropriate antibiotic therapy. Horses • For use in the alleviation of inflammation and relief of pain in both acute and chronic musculo-skeletal disorders. • For the relief of pain associated with equine colic. Dosage & Administration of 20mg/ml Cattle: Single subcutaneous or intravenous injection at a dose rate of 0.5 mg meloxicam/kg bodyweight (i.e. 2.5 ml/100 kg bodyweight) in combination with antibiotic therapy or with oral rehydration therapy as appropriate. Pigs: Single intramuscular injection at a dosage of 0.4 mg meloxicam/kg bodyweight (i.e. 2.0ml/100kg bodyweight) in combination with antibiotic therapy, as appropriate. If required, a second administration of meloxicam can be given after 24 hours. Dosage & Administration of 40mg/ml Cattle: Single subcutaneous or intravenous injection at a dose of 0.5 mg meloxicam/kg body weight (i.e. 1.25 ml/100 kg body weight) in combination with antibiotic therapy or with oral re-hydration therapy, as appropriate. Horses: Single intravenous injection at a dose of 0.6 mg meloxicam/kg body weight (i.e. 1.5 ml/100 kg body weight). For use in the alleviation of inflammation and the relief of pain in both acute and chronic musculo-skeletal disorders, Metacam 15 mg/ml oral suspension may be used for continuation of treatment at a dose of 0.6 mg meloxicam/kg body weight, 24 hours after administration of the injection. Withdrawals: Cattle: Meat and offal - 15 days, Milk - 120 hours. Pigs: Meat and offal - 5 days. Horse meat and offal: 5 days. Not authorised for use in horses producing milk for human consumption.

Metacam 20 mg/ml solution is a non-steroidal anti-inflammatory drug (NSAID) for use in cattle, pigs and horses. Metacam® 40 mg/ml solution for injection for cattle and horses. Cattle: • For use in acute respiratory infection with appropriate antibiotic therapy to reduce clinical signs in cattle. • For use in diarrhoea, in combination with oral rehydration therapy, to reduce clinical signs in calves of over one week of age and young non-lactating cattle. • For adjunctive therapy in the treatment of acute mastitis, in combination with antibiotic therapy. • For the relief of post-operative pain following dehorning in calves. Pigs • For use in non-infectious locomotor disorders to reduce the symptoms of lameness and inflammation. • For adjunctive therapy in the treatment of puerperal septicaemia and toxaemia (mastitis-metritis-agalactia syndrome) with appropriate antibiotic therapy. Horses • For use in the alleviation of inflammation and relief of pain in both acute and chronic musculo-skeletal disorders. • For the relief of pain associated with equine colic. Dosage & Administration of 20mg/ml Cattle: Single subcutaneous or intravenous injection at a dose rate of 0.5 mg meloxicam/kg bodyweight (i.e. 2.5 ml/100 kg bodyweight) in combination with antibiotic therapy or with oral rehydration therapy as appropriate. Pigs: Single intramuscular injection at a dosage of 0.4 mg meloxicam/kg bodyweight (i.e. 2.0ml/100kg bodyweight) in combination with antibiotic therapy, as appropriate. If required, a second administration of meloxicam can be given after 24 hours. Dosage & Administration of 40mg/ml Cattle: Single subcutaneous or intravenous injection at a dose of 0.5 mg meloxicam/kg body weight (i.e. 1.25 ml/100 kg body weight) in combination with antibiotic therapy or with oral re-hydration therapy, as appropriate. Horses: Single intravenous injection at a dose of 0.6 mg meloxicam/kg body weight (i.e. 1.5 ml/100 kg body weight). For use in the alleviation of inflammation and the relief of pain in both acute and chronic musculo-skeletal disorders, Metacam 15 mg/ml oral suspension may be used for continuation of treatment at a dose of 0.6 mg meloxicam/kg body weight, 24 hours after administration of the injection. Withdrawals: Cattle: Meat and offal - 15 days, Milk - 120 hours. Pigs: Meat and offal - 5 days. Horse meat and offal: 5 days. Not authorised for use in horses producing milk for human consumption.