Vaccines

For the active immunisation of cattle against • Parainfluenza3 virus (PI3 virus), to reduce infections. • Bovine Respiratory Syncytial Virus (BRSV) to reduce infection and clinical signs. • Mannheimia (Pasteurella) haemolytica serotype A1, to reduce infection, mortality, clinical signs, lung lesions and bacterial invasion of the lung caused by serotypes A1 and A6. Cross-reactive immunity to the A6 serotype of M. haemolytica has been demonstrated in a challenge experiment under laboratory conditions after a primary course of vaccination. Approximately two weeks after completion of the basic immunisation programme, the humoral immune response against BRS-Virus and PI3-Virus is at its highest level. The duration of protective immunity has not been established in challenge experiments. Dosage & Administration: Vaccination dose: 5 ml by subcutaneous injection at the side of the neck.

For the active immunisation of cattle in order to induce serological and colostral antibody production against Salmonella dublin and Salmonella typhimurium and in the face of an outbreak to reduce Salmonella typhimurium infections when used under field conditions as part of an overall herd management programme. Bovivac S may also contribute to reducing S. typhimurium contamination of the environment. Dosage & Administration • Calves up to 6 months of age - 2 ml • Adult cattle - 5 ml

For the active immunisation of sheep and cattle against diseases caused by Clostridium perfringens type A; C. perfringens type B; C. perfringens type C; C. perfringens type D; C. chauvoei; C. novyi type B; C. septicum; C. sordellii; C. haemolyticum and against tetanus caused by C. tetani. For the passive immunisation of lambs and calves against infection caused by the above mentioned clostridial species (except C. haemolyticum in sheep). The onset of immunity is two weeks after the primary course. Dosage & Administration • Sheep From 2 weeks of age: Dose - 1 ml • Cattle From 2 weeks of age: Dose - 2 ml

For the active immunisation of sheep and cattle against diseases caused by Clostridium perfringens type A; C. perfringens type B; C. perfringens type C; C. perfringens type D; C. chauvoei; C. novyi type B; C. septicum; C. sordellii; C. haemolyticum and against tetanus caused by C. tetani. For the passive immunisation of lambs and calves against infection caused by the above mentioned clostridial species (except C. haemolyticum in sheep). The onset of immunity is two weeks after the primary course. Dosage & Administration • Sheep From 2 weeks of age: Dose - 1 ml • Cattle From 2 weeks of age: Dose - 2 ml

For active immunisation of dogs from 8 weeks of age to reduce coughing caused by Bordetella bronchiseptica. By intranasal administration. Active ingredient: Bordetella bronchiseptica

Target species: Dog Indications for use For active immunisation of dogs from 8 weeks of age to: -prevent mortality and clinical signs of canine distemper and infectious canine hepatitis caused by canine adenovirus type 1; -prevent mortality and clinical signs and reduce excretion caused by canine parvovirus in a challenge study performed with a CPV2b strain; -reduce respiratory clinical signs caused by canine parainfluenza virus; -prevent mortality and reduce infection, clinical signs, kidney colonisation, renal lesions and urine shedding of L. canicola and L. icterohaemorrhagiae; The onset of immunity has been demonstrated from 3 weeks after the primary vaccination for CDV and CPV, 4 weeks for CAV-1 and CPIV, 5 weeks for L. canicola and 2 weeks for L. icterohaemorrhagiae. The duration of immunity lasts for one year after the primary vaccination for all components. For CAV-2 and CPV components, the duration of immunity was demonstrated by

CEVAC® LANDAVAX SC® contains a combination of 2 strains of Pasteurella multocida in inactivated and oil adjuvated form preserved with thiomersal, Pasteurella multocida serotype A1 strain X73 and Pasteurella multocida serotype A3 strain P-1059. INDICATIONS For active immunization of mulard ducks in order to reduce mortality, morbidity and clinical signs associated with infection caused by Pasteurella multocida capsule type A, serovars 1 and 3. ADMINISTRATION AND DOSAGE Administer 1 dose of 0.5 ml by subcutaneous route through ply of the skin into the lower back region of the neck. Vaccination schedule: First injection at 3 weeks of age. Second injection: 3 weeks later.

Sows and gilts: Passive immunisation of piglets via the colostrum, after active immunisation of sows and gilts, to reduce lesions in lymphoid tissues associated with PCV2 infection and as an aid to reduce PCV2-linked mortality. Piglets: Active immunisation of piglets to reduce faecal excretion of PCV2 and virus load in blood, and as an aid to reduce PCV2 linked clinical signs, including wasting, weight loss and mortality as well as to reduce virus load and lesions in lymphoid tissues associated with PCV2 infection.

Inactivated vaccine against swine pleuropeumonia caused by Actinobacillus pleuropeumoniae.

For the active immunisation of sheep and cattle against diseases associated with infections caused by Clostridium perfringens type A, C.perfringens type B, C.perfringens type C, C.perfringens type D, Clostridium chauvoei, Clostridium novyi type B, Clostridium septicum, Clostridium sordellii and Clostridium haemolyticum and against tetanus caused by Clostridium tetani. For the passive immunisation of lambs and calves against infections caused by the above mentioned clostridial species (except C.haemolyticum in sheep). The on Dosage & Administration • Sheep - from 2 weeks of age - 1 ml • Cattle - from 2 weeks of age - 2 ml • Primary vaccination: Two doses should be administered, 4-6 weeks apart. • Booster vaccination: A single dose should be administered at 6 to 12 month intervals.set of immunity is two weeks after the primary course.

For the active immunisation of sheep and cattle against diseases associated with infections caused by Clostridium perfringens type A, C.perfringens type B, C.perfringens type C, C.perfringens type D, Clostridium chauvoei, Clostridium novyi type B, Clostridium septicum, Clostridium sordellii and Clostridium haemolyticum and against tetanus caused by Clostridium tetani. For the passive immunisation of lambs and calves against infections caused by the above mentioned clostridial species (except C.haemolyticum in sheep). The on Dosage & Administration • Sheep - from 2 weeks of age - 1 ml • Cattle - from 2 weeks of age - 2 ml • Primary vaccination: Two doses should be administered, 4-6 weeks apart. • Booster vaccination: A single dose should be administered at 6 to 12 month intervals.set of immunity is two weeks after the primary course.

Porcilis PRRS is a live freeze-dried vaccine containing at least 104.0 TCID50 of PRRS virus strain DV per dose to be reconstituted with Diluvac Forte containing 75 mg/ml dl-a-tocopherol acetate to a suspension for injection. Used to vaccinate breeding and finishing pigs against reproductive and respiratory problems due to PRRS virus. Growing pigs can be vaccinated from 2 weeks of age; a single 2ml intramuscular vaccination will provide protection against the effects of PRRS virus infection through to slaughter weight. PRRS virus can compromise the health, growth and profitability of growing and finishing pigs by causing respiratory problems. Breeding pigs can also be vaccinated with Porcilis PRRS giving a significant improvement in reproductive performance in PRRS positive farms.