An anti-serum against Clostridium tetani for use in horses, sheep and dogs Tetanus Antitoxin Behring is intended for prophylactic use in horses, sheep and dogs to reduce the risk of tetanus infection as a result of accidental injury or as a preoperative precaution. Tetanus Antitoxin Behring is intended for therapeutic use in horses and dogs to increase the recovery rates in animals suffering from clinical tetanus. After subcutaneous and intramuscular injection of Tetanus Antitoxin Behring, maximum serological titres are reached within 2 days. The titre slowly decreases with time, but the protective effect lasts for between 2 and 3 weeks. After intravenous injection, maximum serological titres are reached within three hours and decrease slowly at a similar rate to that following subcutaneous or intramuscular injection. After subarachnoidal injection effective titres in the central nervous system are reached straight after application. The duration of effective antibody titres has not been investigated in the central nervous system.The intravenous and subarachnoidal application routes are recommended for therapeutic use of Tetanus Antitoxin Behring in horses only.
