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Target species: Dog Indications for use For active immunisation of dogs from 8 weeks of age to: -prevent mortality and clinical signs of canine distemper and infectious canine hepatitis caused by canine adenovirus type 1; -prevent mortality and clinical signs and reduce excretion caused by canine parvovirus in a challenge study performed with a CPV2b strain; -reduce respiratory clinical signs caused by canine parainfluenza virus; -prevent mortality and reduce infection, clinical signs, kidney colonisation, renal lesions and urine shedding of L. canicola and L. icterohaemorrhagiae; The onset of immunity has been demonstrated from 3 weeks after the primary vaccination for CDV and CPV, 4 weeks for CAV-1 and CPIV, 5 weeks for L. canicola and 2 weeks for L. icterohaemorrhagiae. The duration of immunity lasts for one year after the primary vaccination for all components. For CAV-2 and CPV components, the duration of immunity was demonstrated by
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