Breeding

Cloprostenol is a synthetic prostaglandin analogue structurally related to Prostaglandin F2α (PGF2α), for use in cattle and horses. As a potent luteolytic agent it causes functional and morphological regression of the corpus luteum (luteolysis) in cattle and horses followed by return to oestrus and normal ovulation. Note There is a refractory period of four to five days after ovulation when cattle and horses are insensitive to the luteolytic effect of prostaglandins. Estrumate has a good safety margin and does not impair fertility. No deleterious effects have been reported on the progeny conceived at the oestrus following treatment. Cattle: • Suboestrus or non-detected oestrus • Induction of parturition • Termination of normal pregnancy • Termination of abnormal pregnancy • Mummified foetus • Hydrops of the foetal membranes • Chronic endometritis (pyometra) • Ovarian luteal cysts • Controlled breeding Cattle: 2ml in lactating cattle. The treatment must be administer immediately after milking. Administer by intramuscular injection observing normal aseptic precautions. Care should be taken to avoid injection through wet or dirty areas of skin. Withdrawals: Cattle: Meat 1day, Milk 0 hours

PMSG is capable of supplementing and being substituted for both luteinising hormone and follicle stimulating gonadotrophin of the anterior pituitary gland in both the male and female, stimulating development of the ovarian follicle. Dosage & Administration Make up immediately before use. • Reconstitute by dissolving the powder plug in about 5 ml of the solvent provided and then syringe the resulting solution into the solvent vial to mix with the remaining solvent. • Administer by subcutaneous or intramuscular injection using normal aseptic precautions. Cow • In conjunction with the use of progestagen treatment when used for oestrus control in non-cycling cattle: 400-700 iu Superovulation: 1500-4000 iu - on day 9-13 of oestrous cycle. Sow • Anoestrus post weaning (induction of oestrus is difficult until 40 days post partum): 1000 iu - s.c. or i.m. Fertile oestrus usually follows in 3 - 7 days. Ewe • In conjunction with progestagen-releasing sponges when used out of the normal breeding season: 500 iu - s.c. or i.m. at time of sponge removal. Withdrawals: Zero days

Cattle: females when used during dioestrus. - synchronisation of oestrus (within 2 to 5 days) in groups of cyclic females. treated simultaneously. persistent corpus luteum (endometritis pyometra). - induction of abortion until day 150 of pregnancy. - induction of parturition (within the last two weeks of gestation). Horses: Pigs: - induction or synchronisation of farrowing (generally within 24 to 36 hours) from. day 113 of pregnancy onwards (day 1 of pregnancy is the last day of natural or. artifi cial insemination). Active ingredient: Cloprostenol.

Active substance: Carbetocin Indications for use, specifying the target species Cow: - Uterine atony during the puerperal period - Placental retention as a consequence of uterine atony - Initiation of milk ejection in stress-induced agalactia or in conditions requiring udder emptying Sow: Acceleration or restart of parturition after disruption of uterine contractions (uterine atony or inertia) following the expulsion of at least 1 piglet -Supportive therapy of mastitis-metritis-agalactia (MMA-) syndrome -Initiation of milk ejection -Shortening of total parturition duration as a component of synchronisation of parturition in sows. The product may be applied to sows which have previously been administered an appropriate PGF2(e.g. cloprostenol) not prior to day 114 of pregnancy and have not started farrowing within 24 hours after the PGF2 injection (day 1 of pregnancy is the last day of insemination)

Active substance: D-Cloprostenol Cattle: Administer 2 ml intramuscular • Synchronisation or induction of oestrus • Induction of parturition; • Ovarian dysfunction (persistent corpus luteum, luteal cyst); • Endometritis/pyometra; • Delayed uterine involution; • Induction of abortion in the first half of pregnancy • Expulsion of mummified foetuses. Pigs: Administer 1ml intramuscular • Induction of parturition. Horses: Administer 1ml intramuscular • Induction of luteolysis in mares with a functional corpus luteum. Withdrawal period(s): Cattle: Meat and offal: Zero days, Milk: Zero hours Pigs Meat and offal: 1 day Horses: Meat and offal: 2 days, Milk: Zero hours

Intramuscular injection for use for its luteolytic and/or owytocic effects. CATTLE: 5ml, MARES: 1ml, PIGS: 2ml Withdrawal: MEAT AND OFFAL: 1 day, MILK: Nil. Active ingredient: Dinoprost

Intramuscular injection for use for its luteolytic and/or owytocic effects. CATTLE: 5ml, MARES: 1ml, PIGS: 2ml Withdrawal: MEAT AND OFFAL: 1 day, MILK: Nil. Active ingredient: Dinoprost

White sponges impregnated with 20mg micronised cronolone (flugestone acetate) for use in ewes. It is recommended sponges are inserted intravaginally using a correct vaginal applicator to avoid injury. Active ingredient: Cronolone

Uterine inertia, retention of the placenta, agalactia, prevention of haemorrhages after caesarean section or hard delivery. Active ingredient: Oxytocin

For induced parturition, aid to parturition, stimulate involution of the uterus and stimulate milk let down for a range of animals. Active ingredient: Oxytocin

An injectable hormone containing human chorionic gonadotrophin (hCG) and equine chorionic gonadotrophin (ECG - Also known as Pregnant Mare Serum Gonadotrophin (PMSG)) for use in pigs. This product may only be prescribed by your veterinary practitioner from whom advice must be sought. Active ingredient: Chorionic Gonadotrophin

A synthetic prostaglandin analogue for use in pigs containing cloprostenol. This product may only be prescribed by your veterinary practitioner from whom advice should be sought. Active ingredient: Cloprostenol